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目的 观察生物陶瓷材料iRoot BP Plus用于成熟恒牙不可复性牙髓炎活髓切除术的疗效。方法 选择2022年3月至2024年3月西安交通大学口腔医院收治的成熟恒牙不可复性牙髓炎患者100例(100颗患牙)为研究对象，按照简单随机法分为对照组和试验组，每组50例(各50颗患牙)。对照组使用三氧化矿物凝聚体(MTA)盖髓剂行活髓切除术，试验组使用生物陶瓷材料iRoot BP Plus盖髓剂行活髓切除术。比较两组患者疼痛程度、临床疗效、影像学疗效及牙齿变色率。结果 术后第1天和第7天，两组患者视觉模拟评分法(VAS)评分均较术前降低(P<0.05)，术后第7天较术后第1天下降(P<0.05)，且术后第1天和第7天试验组VAS评分低于对照组同期(P<0.05)。术后3、6、12个月，试验组临床成功率分别为96.00%、94.00%、94.00%，对照组分别为94.00%、92.00%、90.00%，两组比较，差异均无统计学意义(P>0.05)。术后3、6、12个月，试验组影像学成功率分别为96.00%、92.00%、92.00%，对照组分别为92.00%、90.00%、90.00%，两组比较，差异均无统计学意义(P>0.05)。术后12个月，试验组牙齿变色率为2.00%(1/50)，低于对照组的46.00%(23/50)(χ2=26.535,P<0.05)。结论 在成熟恒牙不可复性牙髓炎的活髓切除术中，使用生物陶瓷材料iRoot BP Plus的短期和长期疗效与MTA相当，但在减轻术后疼痛和避免牙齿变色方面更具优势。
Abstract：Objective To observe the efficacy of the bioceramic material iRoot BP Plus in vital pulpotomy for irreversible pulpitis of mature permanent teeth. Methods A total of 100 patients(100 affected teeth) with irreversible pulpitis of mature permanent teeth admitted to the School of Stomatology, Xi'an Jiaotong University from March 2022 to March 2024 were selected as the study subjects. They were divided into a control group and an experimental group by simple randomization, with 50 cases in each group(50 affected teeth each). The control group underwent pulpotomy using mineral trioxide aggregate(MTA) as the pulp capping agent, while the experimental group underwent pulpotomy using the bioceramic material iRoot BP Plus as the pulp capping agent. Pain level, clinical efficacy, radiographic efficacy, and tooth discoloration rate were compared between the two groups. Results On the first and seventh days after surgery, the visual analog scale(VAS) scores of both groups decreased compared with those before surgery(P<0.05), and the scores on day 7 were lower than those on day 1(P<0.05). The VAS scores of the experimental group were lower than those of the control group on both day 1 and day 7 after surgery(P<0.05). At 3, 6, and 12 months after surgery, the clinical success rates of the experimental group were 96.00%, 94.00%, and 94.00%, respectively, while those of the control group were 94.00%, 92.00%, and 90.00%, respectively, with no statistically significant differences between the two groups(P>0.05). At 3, 6, and 12 months after surgery, the radiographic success rates of the experimental group were 96.00%, 92.00%, and 92.00%, respectively, while those of the control group were 92.00%, 90.00%, and 90.00%, respectively, with no statistically significant differences between the two groups(P>0.05). At 12 months after surgery, the tooth discoloration rate of the experimental group was 2.00%(1/50), which was lower than that of the control group at 46.00%(23/50)(χ2=26.535, P<0.05). Conclusion In vital pulpotomy for irreversible pulpitis of mature permanent teeth, the short-term and long-term efficacy of iRoot BP Plus is comparable to that of MTA, but it shows advantages in reducing postoperative pain and preventing tooth discoloration.
[1]Kahler B,Taha NA,Lu J,et al. Vital pulp therapy for permanent teeth with diagnosis of irreversible pulpitis:biological basis and outcome[J].Aust Dent J,2023,68(Suppl 1):S110-S122. DOI:10.1111/adj.12997.
[2]曾亚军，何其佳，周杰.维他派克斯糊剂联合干髓糊剂在乳牙牙髓炎中的应用效果评价[J].中国药物应用与监测，2024,21(4):454-457. DOI:10.3969/j.issn.1672-8157.2024.04.033.
[3]Lin LM,Ricucci D,Saoud TM,et al. Vital pulp therapy of mature permanent teeth with irreversible pulpitis from the perspective of pulp biology[J]. Aust Endod J,2020,46(1):154-166. DOI:10.1111/aej.12392.
[4]Ather A,Patel B,Gelfond JAL,et al. Outcome of pulpotomy in permanent teeth with irreversible pulpitis:a systematic review and meta-analysis[J]. Sci Rep,2022,12(1):19664. DOI:10.1038/s41598-022-20918-w.
[5]Herbst SR,Pitchika V,Herbst CS,et al. Effectiveness of calcium hydroxide compared to hydraulic calcium silicate cements for direct pulp capping in managing deep caries in vital permanent teeth:a systematic review and meta-analysis[J]. Int Endod J,2025,58(8):1110-1125. DOI:10.1111/iej.14256.
[6]Shaik I,Dasari B,Kolichala R,et al. Comparison of the success rate of mineral trioxide aggregate,endosequence bioceramic root repair material,and calcium hydroxide for apexification of immature permanent teeth:systematic review and meta-analysis[J]. J Pharm Bioallied Sci,2021,13(Suppl 1):S43-S47. DOI:10.4103/jpbs.JPBS_810_20.
[7]Maru V,Dixit U,Patil RSB,et al. Cytotoxicity and bioactivity of mineral trioxide aggregate and bioactive endodontic type cements:a systematic review[J]. Int J Clin Pediatr Dent,2021,14(1):30-39.DOI:10.5005/jp-journals-10005-1880.
[8]Yang N,Yang W,Shen R,et al. In vitro and in vivo evaluation of iRoot BP Plus as a coronal sealing material for regenerative endodontic procedures[J]. Clin Oral Investig,2024,28(1):70. DOI:10.1007/s00784-023-05468-3.
[9]张自婕，郭凯瑞，焦宁华，等.复方阿嗪米特治疗重度糜烂性胃炎并发消化不良患者的效果及其对胃黏膜功能恢复的影响[J].感染、炎症、修复，2024,25(2):100-103. DOI:10.3969/j.issn.1672-8521.2024.02.004.
[10]秦志明，李佳洋，徐华兴，等.成熟恒牙龋源性不可复性牙髓炎活髓保存治疗的临床疗效观察[J].复旦学报(医学版)，2025,52(2):263-269. DOI:10.3969/j.issn.1672-8467.2025.02.013.
[11]Kalantzis N,Gioti M,Sofia F,et al. The management of deep carious lesions and the exposed pulp in fully developed and immature teeth with irreversible pulpitis:a questionnaire-based study among Greek dentists[J].Clin Oral Investig,2024,28(7):359. DOI:10.1007/s00784-024-05756-6.
[12]Taha NA,Abuzaid AM,Khader YS. A randomized controlled clinical trial of pulpotomy versus root canal therapy in mature teeth with irreversible pulpitis:outcome,quality of life,and patients'satisfaction[J]. J Endod,2023,49(6):624-631. e2. DOI:10.1016/j.joen.2023.04.001.
[13]Rueda-Ibarra V,Robles-Bermeo NL,González-López BS,et al.Full pulpotomy as a treatment for irreversible pulpitis in permanent teeth:a systematic review of the literature based on case reports[J].Cureus,2023,15(10):e46808. DOI:10.7759/cureus.46808.
[14]Jiménez-Martín C,Martín-González J,Crespo-Gallardo I,et al. Elective full pulpotomy in mature permanent teeth diagnosed with symptomatic irreversible pulpitis:a two years retrospective study[J]. Clin Oral Investig,2024,28(8):421. DOI:10.1007/s00784-024-05814-z.
[15]Tzanetakis GN,Koletsi D,Georgopoulou M. Treatment outcome of partial pulpotomy using two different calcium silicate materials in mature permanent teeth with symptoms of irreversible pulpitis:a randomized clinical trial[J]. Int Endod J,2023,56(10):1178-1196.DOI:10.1111/iej.13955.
[16]Peters E,Kratunova E,Lamberghini F,et al. Premixed mineral trioxide aggregate setting reaction in primary molar pulpotomies[J]. J Dent Child,2023,90(1):11-16.
[17]Ma X,Xu H,Chen X,et al. Modern methods and materials used to treat root perforation:effectiveness comparison[J]. J Mater Sci Mater Med,2024,35(1):1. DOI:10.1007/s10856-023-06770-y.
[18]Dong X,Su Q,Li W,et al. The outcome of combined use of iRoot BP Plus and iRoot SP for root-end filling in endodontic microsurgery:a randomized controlled trial[J]. Clin Oral Investig,2024,28(3):188. DOI:10.1007/s00784-024-05569-7.
[19]Thanatipanont N,Louwakul P. Comparison of marginal adaptation,surface hardness and bond strength of resected and retrofilled calcium silicate-based cements used in endodontic surgery:an in vitro study[J]. J Contemp Dent Pract,2023,24(9):638-644. DOI:10.5005/jp-journals-10024-3562.
[20]王霄燕，李宏，石晶. MTA和iRoot BP Plus对乳牙活髓切断术的临床疗效影响[J].实用口腔医学杂志，2019,35(5):672-674.DOI:10.3969/j.issn.1001-3733.2019.05.010.
[21]Abou Elreash A,Hamama H,Grawish M,et al. A laboratory study to test the responses of human dental pulp stem cells to extracts from three dental pulp capping biomaterials[J]. Int Endod J,2021,54(7):1118-1128. DOI:10.1111/iej.13495.
[22]Lai G,Sheng K,Zhao J,et al. A retrospective study on the outcome of pulpotomy with iRoot BP plus in primary molars and its relationship with hemostasis time[J]. BMC Oral Health,2024,24(1):1134.DOI:10.1186/s12903-024-04816-3.
[23]李静，尹俊，郝怡然，等.富血小板纤维蛋白对正畸拔牙术后疼痛、牙周组织变化及牙齿移动的影响[J].转化医学杂志，2025,14(4):119-124. DOI:10.3639/j.issn.2095-3097.2025.04.023.
基本信息:
中图分类号:R781.31
引用信息:
[1]孟亚军,李莉,董少杰,等.生物陶瓷材料iRoot BP Plus用于成熟恒牙不可复性牙髓炎活髓切除术疗效评价[J].转化医学杂志,2026,15(01):20-24.
基金信息:
陕西省重点研发计划项目（2022SF-146）; 西安市科技计划项目（21YXYJ0123）
2026-01-19
2026-01-19