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由于外泌体在肿瘤等疾病的基础研究、转化应用和诊断治疗中展现出的巨大潜力而备受瞩目。在发展精准医疗产业的背景下,如何建立相关领域的标准与规范,促进产学研结合,理性引导技术转化,需要来自于基础科研、临床、检验等领域的专家,以及监管部门的多方参与合作。为推动和促进国内外泌体特别是外泌体肿瘤标志物的研究和转化应用的有序开展,中国抗癌协会肿瘤标志专业委员会外泌体技术专家委员会组织专家撰写了外泌体研究、转化和临床应用专家共识。在本共识中,就外泌体研究领域的发展历程与现状阐述了观点及立场,并对外泌体研究的未来方向进行了展望。
Abstract：Exosomes are end products of the recycling endosomal pathway and originate from inward budding of plasma membrane,which is different from other types of extracellular vesicles.Given that disease-derived exosomes are detectable in body fluids globally and contain all levels of molecular profiles of cells of origin,exosomes are emerging as a new addition of liquid biopsy. In this consensus statement,the authors discuss their current views on the exosome-relevant studies and product research/development with the common opinion of translating the new knowledge acquired into clinical practice in cancers and other diseases. Overall point of consensus includes the common vision of merits,unresolved questions and current challenges of exosomes. Specific points of consensus include the development of exosomes as the disease biomarkers. This consensus manuscript is an initiative of the Committee of Exosomes,Society of Tumor Markers,Chinese anti-Cancer Association.
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基本信息:
中图分类号:R446.1
引用信息:
[1]张灏,赵立波,叶国栋.外泌体研究、转化和临床应用专家共识[J].转化医学杂志,2018,7(06):321-325.
2018-12-20
2018-12-20