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目的 探讨淋巴管发育关键基因群前同源盒基因1(PROX1)、叉头框蛋白C2(FOXC2 )和血管内皮生长因子受体3(VEGFR3)与自发性乳糜疾病的相关性。方法 回顾性选取2019年1月至2023年12月上海市浦东新区浦南医院收治的25例自发性乳糜疾病患者为患者组，另选取同期体检的20例健康志愿者为对照组，比较两组受试者PROX1、FOXC2、VEGFR3蛋白及基因表达水平。结果 25例自发性乳糜疾病患者中，乳糜尿11例，乳糜腹6例，乳糜胸8例。患者组与对照组PROX1、FOXC2及VEGFR3全血蛋白表达水平比较，差异无统计学意义(P>0.05)；患者组PROX1、FOXC2及VEGFR3的mRNA表达水平均高于对照组(P<0.05)，乳糜尿、乳糜胸、乳糜腹患者PROX1和FOXC2表达水平比较，差异均无统计学意义(P>0.05)。结论 PROX1、FOXC2及VEGFR3基因在自发性乳糜疾病中表达上调，提示这些基因可能通过影响淋巴管结构和功能参与疾病的发生和发展。
Abstract：Objective To investigate the correlation between key lymphatic development genes prospero homeobox 1(PROX1), forkhead box protein C2(FOXC2), and vascular endothelial growth factor receptor 3(VEGFR3) in spontaneous chylous disorders. Methods A retrospective study was conducted from January 2019 to December 2023. Twenty-five patients with spontaneous chylous disorders were selected as the patient group, and 20 healthy volunteers undergoing physical examination during the same period were selected as the control group from Shanghai Pudong New Area Punan Hospital. Protein and mRNA expression levels of PROX1, FOXC2, and VEGFR3 in whole blood were compared between the two groups. Results Among the 25 patients with spontaneous chylous disorders, there were 11 cases of chyluria, 6 cases of chylous ascites, and 8 cases of chylothorax. No statistically significant difference was found in whole blood protein expression levels of PROX1, FOXC2, and VEGFR3 between the control group and the patient group(P>0.05); However, mRNA expression levels of PROX1, FOXC2, and VEGFR3 were significantly higher in the patient group than in the control group(P<0.05). There were no statistically significant differences in PROX1 and FOXC2 expressions among patients with chyluria, chylothorax and chylous ascites(P>0.05). Conclusion The upregulation of PROX1, FOXC2, and VEGFR3 gene expression in spontaneous chylous diseases suggests that these genes may be involved in the occurrence and development of the disease by affecting lymphatic structure and function.
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基本信息:
中图分类号:R656
引用信息:
[1]俞家顺,夏维木,唐崎,等.自发性乳糜疾病患者PROX1、FOXC2和VEGFR3基因表达模式的研究[J].转化医学杂志,2026,15(01):25-29.
基金信息:
国家自然科学基金(82270707); 浦东新区卫生健康委员会学科建设计划项目(PWZzb2022-07);浦东新区卫生健康委员会学科带头人人才计划项目(PWRd2022-07); 浦东新区科技发展基金事业单位民生科研专项医疗项目(PKJ2025-Y30)
2026-01-19
2026-01-19